Metastatic cells can escape the pro-apoptotic effects of TNF-α through increased autocrine IL-6/STAT3 signalling
نویسندگان
چکیده
∞ This study was supported by grant MOP-81201 from the Canadian Institute for Health Research. # Supported by a doctoral fellowship from the Research Institute of the McGill University Health Center. * To whom all correspondence should be addressed at: McGill University Health Center Royal Victoria Hospital, Room H6.25 687 Pine Ave. W., Montreal, QC., Canada H3A 1A1 Telephone: (514) 934-1934 (Ext. 36692) Fax: (514) 843-1411 Email: [email protected]
منابع مشابه
Metastatic cells can escape the proapoptotic effects of TNF-α through increased autocrine IL-6/STAT3 signaling.
The liver is a common site for cancer metastases in which the entrance of tumor cells has been shown to trigger a rapid inflammatory response. In considering how an inflammatory response may affect metastatic colonization in this setting, we hypothesized that tumor cells may acquire resistance to the proapoptotic and tumoricidal effects of TNF-α, a cytokine that is elevated in a proinflammatory...
متن کاملMicroenvironment and Immunology Metastatic Cells Can Escape the Proapoptotic Effects of TNF-a through Increased Autocrine IL-6/STAT3 Signaling
The liver is a common site for cancermetastases in which the entrance of tumor cells has been shown to trigger a rapid inflammatory response. In considering how an inflammatory responsemay affectmetastatic colonization in this setting, we hypothesized that tumor cells may acquire resistance to the proapoptotic and tumoricidal effects of TNF-a, a cytokine that is elevated in a proinflammatory ti...
متن کاملTNF-α Affects Human Cortical Neural Progenitor Cell Differentiation through the Autocrine Secretion of Leukemia Inhibitory Factor
Proinflammatory cytokine tumor necrosis factor-alpha (TNF-α) is a crucial effector of immune responses in the brain that participates in the pathogenesis of several acute and chronic neurodegenerative disorders. Accumulating evidence has suggested that TNF-α negatively regulates embryonic and adult neurogenesis. However, the effect of TNF-α on cell fate decision in human neural progenitor cells...
متن کاملAnnexin A1 released from apoptotic cells acts through formyl peptide receptors to dampen inflammatory monocyte activation via JAK/STAT/SOCS signalling
The immunosuppressive effects of apoptotic cells involve inhibition of pro-inflammatory cytokine release and establishment of an anti-inflammatory cytokine profile, thus limiting the degree of inflammation and promoting resolution. We report here that this is in part mediated by the release of the anti-inflammatory mediator annexin A1 from apoptotic cells and the functional activation of annexi...
متن کاملIn vitro and in vivo assessment of inhibitory effect of stevioside on pro-inflammatory cytokines
Objective: Stevioside is a natural non-caloric sweetener which has been reported to have anti-inflammatory activity. The aim of the present study was to examine in vitro and in vivo effects of stevioside on rats plasma levels of tumor necrosis factor- α (TNF-α), interleukin-1β (IL-1β), TNF-α and IL-1β release from lipopolysaccharide(LPS)-stimulated rat peripheral blood mononuclear cells (P...
متن کامل