Metastatic cells can escape the pro-apoptotic effects of TNF-α through increased autocrine IL-6/STAT3 signalling
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چکیده
∞ This study was supported by grant MOP-81201 from the Canadian Institute for Health Research. # Supported by a doctoral fellowship from the Research Institute of the McGill University Health Center. * To whom all correspondence should be addressed at: McGill University Health Center Royal Victoria Hospital, Room H6.25 687 Pine Ave. W., Montreal, QC., Canada H3A 1A1 Telephone: (514) 934-1934 (Ext. 36692) Fax: (514) 843-1411 Email: [email protected]
منابع مشابه
Metastatic cells can escape the proapoptotic effects of TNF-α through increased autocrine IL-6/STAT3 signaling.
The liver is a common site for cancer metastases in which the entrance of tumor cells has been shown to trigger a rapid inflammatory response. In considering how an inflammatory response may affect metastatic colonization in this setting, we hypothesized that tumor cells may acquire resistance to the proapoptotic and tumoricidal effects of TNF-α, a cytokine that is elevated in a proinflammatory...
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The liver is a common site for cancermetastases in which the entrance of tumor cells has been shown to trigger a rapid inflammatory response. In considering how an inflammatory responsemay affectmetastatic colonization in this setting, we hypothesized that tumor cells may acquire resistance to the proapoptotic and tumoricidal effects of TNF-a, a cytokine that is elevated in a proinflammatory ti...
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تاریخ انتشار 2011